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Spain's health ministry said the MV Hondius is expected to arrive within three to four days.
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Two crew members, including the ship's reportedly British doctor, require urgent medical care and were due to be evacuated on a hospital aircraft to the Canary Islands on Tuesday. A third person linked to a German national who died was also due to be evacuated.
Officials were determining which passengers required urgent evacuation from Cape Verde, where the ship was docked, the health ministry added.
Three passengers who were aboard the MV Hondius have died, after it set sail from Argentina on its voyage across the Atlantic Ocean around a month ago.
Seven cases of hantavirus - two confirmed and five suspected - have so far been identified in people who were on the ship, according to the latest World Health Organization (WHO) update.
The two confirmed cases are a Dutch woman, who is among those who died, and a 69-year-old UK national who was evacuated to South Africa for medical treatment.
The woman's husband also died but he is not a confirmed case, nor is the German national who passed away on 2 May.
South Africa's health ministry said the two confirmed cases are linked to the Andes strain of hantavirus, according to a Reuters report. That strain is known to cause human-to-human transmission between people in close contact.
Some 149 people from 23 countries remained aboard under "strict precautionary measures", the ship's operator Oceanwide Expeditions said.
Aside from the British crew member, there are 22 other British nationals on board.
Spain's health ministry said the remaining passengers would go on to the Canary Islands, where they were expected to arrive within three to four days, adding that the exact port had not yet been decided.
Cruise operator Oceanwide Expeditions said its plan was to sail to "Gran Canaria or Tenerife".
It said the World Health Organization (WHO) had explained that Cape Verde "cannot carry out this operation&
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