"She is without any medicine. She needs it to survive," says the NBC host about missing 84-year-old Nancy Guthrie.
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"We want to hear from you and we are ready to listen," the NBC host says, flanked by her siblings in the clip posted to Instagram. "Please reach out to us."
Nancy Guthrie went missing in the middle of the night from her home in the US state of Arizona over the weekend.
Authorities said they suspect she was kidnapped and they are working with the FBI to authenticate a possible ransom note.
"We are ready to talk," said the NBC host in the video posted on Wednesday night. "However, we live in a world where voices and images are easily manipulated.
"We need to know without a doubt that she is alive and that you have her."
It is standard procedure in hostage and kidnap cases for negotiators to demand proof of life from abductors. It is unclear if Nancy Guthrie's children were directed to do so by authorities.
Pima County Sheriff's Office said on Wednesday they were still speaking with anyone who had contact with Nancy Guthrie last weekend, and that no suspect or person of interest had so far been identified.
Savannah Guthrie, joined by her sister Annie and brother Cameron, said in the clip they were aware of an alleged ransom note, which was sent to at least one media outlet.
"Mommy, if you are hearing this, you are a strong woman," the Today show presenter said, her voice breaking.
"Everyone is looking for you, mommy. Everywhere. We will not rest. Your children will not rest until we are together again."
Officials have warned Nancy Guthrie could be in dire health without her medication, which Savannah Guthrie mentioned in the clip.
"Our mom is our heart and our home," she said. "Her health, her heart is fragile. She lives in constant pain.
"She is without any medicine. She needs it to survive. She needs it not to suffer."
Her sister, An
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