The US president says "we will come to their rescue" after days of demonstrations and clashes.
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In a brief post on social media, he wrote: "We are locked and loaded and ready to go." He gave no further details.
A senior adviser to Iran's Supreme Leader, Ayatollah Ali Khamenei, responded by saying Trump should "be careful" if he intervened, warning of potential chaos across the Middle East.
At least six people are reported to have been killed in Iran on Thursday after almost a week of mass protests sparked by worsening economic conditions.
In Friday's post on Truth Social, Trump wrote: "If